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RAS BiologyРадиационная биология. Радиоэкология Radiation biology. Radioecology

  • ISSN (Print) 0869-8031
  • ISSN (Online) 3034-5898

Morphological Changes in the Vaculous Plexus of the Lateral Ventriles of the Brain of Rats after Prolonged Exposure to Low-Intense γ-Radiation

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PII
S30345898S0869803125020077-1
DOI
10.7868/S3034589825020077
Publication type
Article
Status
Published
Authors
O.A. Fokanova
  • Occupation: MD
  • Affiliation: Yaroslavl State Medical University, Ministry of Health of the Russian Federation
T.V. Korableva
  • Occupation: MD
  • Affiliation: Yaroslavl State Medical University, Ministry of Health of the Russian Federation
O.V. Ermakova
  • Occupation: BD
  • Affiliation: Institute of Biology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
Volume/ Edition
Volume 65 / Issue number 2
Pages
201-207
Abstract
Experiments to study the morphological features of the choroid plexus of the ventricles of the brain were performed on Wistar rats of reproductive age, which were divided into 3 groups of 7 animals: 1 – control and 2 and 3 – chronic irradiation (absorbed doses – 5 and 50 cGy). Irradiation was carried out using a Foton-1 installation from a Cs source. The experiments were carried out on anesthetized animals. For analysis, histological preparations of serial sections of the lateral ventricles of the brain were used. To assess the volume of the lateral ventricles, sections were selected where the cross-sectional area was maximum. The following morphofunctional rearrangements were recorded: a decrease in the relative volume of the choroid plexuses, as well as the fraction of cells in the plexuses, a decrease in the height of epithelial cells, swelling of cells, erasure of their contours, vacuolization of the cytoplasm. An increase in the volume fraction of blood vessels and a relatively tight fit of individual loops of blood vessels with each other with phenomena of disorganization were observed. Areas of dystrophic changes not only in the choroid plexus, but also in the brain substance have been recorded. The conducted studies indicate that chronic γ-radiation affects the morphological characteristics of the choroid plexus of the ventricles of the brain and expands the understanding of the effect of low-intensity ionizing radiation on the brain, which can be a potential risk factor leading to plexus dysfunction and disruption of liquor dynamics and blood supply.
Keywords
головной мозг крысы сосудистое сплетение низкоинтенсивное γ-излучение ликвор гематоликворный барьер
Date of publication
29.12.2025
Year of publication
2025
Number of purchasers
0
Views
57

References

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